Sedative medicines including benzodiazepines or related medication: The concomitant usage of opioids with sedative medicines such as benzodiazepines or related medicine boosts the risk of sedation, respiratory depression, coma and Demise due to additive CNS depressant impact. The dose and period of concomitant use must be minimal (see segment four.4). https://larryn496iaq8.wikirecognition.com/user